MDM4-targeting ASO (sodium)

MedChem Express

MDM4-targeting ASO (sodium)

5

Research Use Only

MDM4-targeting ASO sodium is a 25mer antisense oligonucleotide targeting? MDM4 . MDM4-targeting ASO sodium induced exon 6 skipping, leading to nonsense-mediated decay of the mRNA transcript that excludes exon-6. In multiple human melanoma cell lines and in melanoma patient-derived xenograft (PDX) mouse models, MDM4-targeting ASO-mediated skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting therapeutics.

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