MDM4-targeting ASO (sodium)
HY-158830
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameMDM4-targeting ASO (sodium)
- Delivery Days Customer5
- CertificationResearch Use Only
- Scientific DescriptionMDM4-targeting ASO sodium is a 25mer antisense oligonucleotide targeting MDM4. MDM4-targeting ASO sodium induced exon 6 skipping, leading to nonsense-mediated decay of the mRNA transcript that excludes exon-6. In multiple human melanoma cell lines and in melanoma patient-derived xenograft (PDX) mouse models, MDM4-targeting ASO-mediated skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting therapeutics.
- SMILES[MDM4-targeting ASO (sodium)]
- UNSPSC41115811