ME-344
HY-112749
Estimated Purity98.12
Product group Chemicals
Molecular Weight348.39
Overview
- SupplierMedChem Express
- Product NameME-344
- Delivery Days Customer5
- CertificationResearch Use Only
- Estimated Purity98.12
- Molecular FormulaC22H20O4
- Molecular Weight348.39
- Scientific DescriptionME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research[1].
- SMILESOC1=CC=C2[C@H](C3=CC=C(O)C=C3)[C@H](C4=CC=C(O)C=C4)COC2=C1C
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200