Western blot detection of Mek1 protein in RAW cell (1) and RBL transfected with NIK(2).
Western blot detection of Mek1 protein in RAW cell (1) and RBL transfected with NIK(2).
MEK1 antibody
GTX45127
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetMap2k1
Overview
- SupplierGeneTex
- Product NameMEK1 antibody
- Delivery Days Customer9
- Antibody SpecificityMEK1 in RAW cell and RBL transfected with NIK
- ApplicationsImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID26395
- Target nameMap2k1
- Target descriptionmitogen-activated protein kinase kinase 1
- Target synonymsdual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK1; Mek1; MEKK1; Prkm; Prkmk1; protein kinase, mitogen activated, kinase 1, p45
- HostRabbit
- IsotypeIgG
- Scientific DescriptionMAP2K1, MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203