MEK/RAF-IN-1
HY-162873
Molecular Weight618.63
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameMEK/RAF-IN-1
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC28H29F3N6O5S
- Molecular Weight618.63
- Scientific DescriptionMEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC50 values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer[1].
- SMILESFC1=C(NC2=C(F)C=C(C3CC3)C=C2)C(C(NOCCO)=O)=CC4=C1N=CN4CC5=C(F)C(NS(=O)(NCC)=O)=CC=C5
- UNSPSC12352200