MEL23

MedChem Express

MEL23 [642072-49-9]

5

Research Use Only

C19H22N4O3

354.40

MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription[1].

O=C1NC(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1CCCC)=O)=O

12131703