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Menin-MLL inhibitor MI-2 [1271738-62-5]

HY-15222
MedChem Express
CAS Number1271738-62-5
Product group Chemicals
Estimated Purity99.81
Molecular Weight375.55
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Menin-MLL inhibitor MI-2 [1271738-62-5]
  • Delivery Days Customer
    5
  • CAS Number
    1271738-62-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.81
  • Molecular Formula
    C18H25N5S2
  • Molecular Weight
    375.55
  • Scientific Description
    Menin-MLL inhibitor MI-2 is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL)[1].
  • SMILES
    CCCC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200