Metformin

MedChem Express

Metformin [657-24-9]

9

657-24-9

Research Use Only

99.98

C4H11N5

129.167

Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] [2] [3] [4] [5] [6] [7] .

NC(NC(N(C)C)=N)=N

-20°C

12352200