Methoxy-X04 --- Fluorescent Amyloid beta (Abeta) Probe [863918-78-9] [863918-78-9]

Bioss

Methoxy-X04 --- Fluorescent Amyloid beta (Abeta) Probe [863918-78-9] [863918-78-9]

16

863918-78-9

Research Use Only

Unconjugated

98 - 98.0

C23 H20 O3

344.4

Methoxy-X04 is a fluorescent amyloid beta (Abeta) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid with good specificity. It is a derivative of Congo red and Chrysamine-G that contains no acid groups and is therefore smaller and much more lipophilic than Congo red or Chrysamine-G. Methoxy-X04 retains in vitro binding affinity for amyloid beta (Abeta) fibrils (Ki = 26.8 nM) very similar to that of Chrysamine-G. Using multiphoton microscopy to obtain high-resolution (1 microm) fluorescent images from the brains of living PSI/APP mice, individual plaques could be distinguished within 30 to 60 min after a single IV injection or a single IP injection of Methoxy-X04.

COC1C=C(/C=C/C2C=CC(O)=CC=2)C=CC=1/C=C/C1C=CC(O)=CC=1

-20°C

41115811