Methyl-L-NIO (hydrochloride) [150403-96-6]

MedChem Express

Methyl-L-NIO (hydrochloride) [150403-96-6]

5

150403-96-6

Research Use Only

C8H18ClN3O2

223.70

Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 microM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 microM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1].

N[C@@H](CCCNC(CC)=N)C(O)=O.Cl

12352200