Methyltetrazine-PEG4-hydrazone-DBCO

MedChem Express

Methyltetrazine-PEG4-hydrazone-DBCO

5

Research Use Only

90.0

C48H51N9O8

881.97

Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

O=C(CCC(N/N=C\C1=CC=C(C(NCCOCCOCCOCCOCCC(NCC2=CC=C(C3=NN=C(C)N=N3)C=C2)=O)=O)C=C1)=O)N4C5=CC=CC=C5C#CC6=CC=CC=C6C4

-20°C

41115800