Metopimazine [14008-44-7]

MedChem Express

Metopimazine [14008-44-7]

10

14008-44-7

Research Use Only

99.75

C22H27N3O3S2

445.60

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3].

O=C(N)C1CCN(CC1)CCCN2C3=C(SC4=CC=C(C=C24)S(=O)(C)=O)C=CC=C3

-20°C,2°C to 8°C

12352200