MET/PDGFRA-IN-1

MedChem Express

MET/PDGFRA-IN-1

14

Research Use Only

C26H23N7O

449.51

MET/PDGFRA-IN-1 (compound 8c) is a MET and PDGFRA protein inhibitor (IC50: 36 microM for MET). MET/PDGFRA-IN-1 inhibits MET phosphorylation and induces cell apoptosis. MET/PDGFRA-IN-1 inhibits proliferation of MET-positive cells (IC50s: 15.3, 19.0, 22.0, 25.6, 21.0, 31.5 microM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively)[1].

CC1=CC=C(C=C1)CN2N=NC(COC3=CC=C(C=C3)/C=N/NC4=C5C=CC=CC5=NC=N4)=C2

12352200