MHC II (HLA-DQ)(SPV-L3), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

MHC II (HLA-DQ)(SPV-L3), CF405S conjugate, 0.1mg/mL

9

Functional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

SPV-L3

0.1 mg/ml

Other Conjugate

HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

CELIAC1; DC-1 alpha chain; DC-alpha; DQA1; DQ-A1; HLA class II histocompatibility antigen DQ alpha chain; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; HLA-DQA; MHC class II antigen DQA1; MHC class II DQ alpha chain; MHC class II DQA1; MHC class II HLA-DQ-alpha-1; MHC class II protein; MHC HLA-DQ alpha; truncated MHC class II antigen

Mouse

IgG2a

HLA class II histocompatibility antigen, DQ alpha 1 chain

Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C

12352203