mHTT-IN-1 [2839311-21-4]

MedChem Express

mHTT-IN-1 [2839311-21-4]

10

2839311-21-4

Research Use Only

C18H19N7OS

381.45

mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntingtons disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].

O=C1C=C(C2=NN3C=C(C)N=C3C(C)=C2)N=C4SC(N5CCNCC5)=CN14

12131703