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MI-2-2

HY-108350
MedChem Express
CAS Number1454920-20-7
DownloadMSDS
Product group Chemicals
Estimated Purity99.92
Molecular Weight415.50
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MI-2-2 [1454920-20-7]
  • Delivery Days Customer
    10
  • CAS Number
    1454920-20-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.92
  • Molecular Formula
    C17H20F3N5S2
  • Molecular Weight
    415.50
  • Scientific Description
    MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation [1] .
  • SMILES
    FC(F)(F)CC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200