MICAL1 Antibody

Cusabio

MICAL1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

MICAL1

microtubule associated monooxygenase, calponin and LIM domain containing 1

[F-actin]-methionine sulfoxide oxidase MICAL1; [F-actin]-monooxygenase MICAL1; MICAL; MICAL-1; molecule interacting with CasL protein 1; NEDD9-interacting protein with calponin homology and LIM domains; NICAL; protein-methionine sulfoxide oxidase MICAL1

Rabbit

IgG

[F-actin]-monooxygenase MICAL1

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of sectrory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.

-20°C or -80°C

12352203