Micheliolide

MedChem Express

Micheliolide [68370-47-8]

10

68370-47-8

Research Use Only

99.77

C15H20O3

248.322

Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-kappaB activation, IkappaBalpha degradation, and the expression of MCP-1, TGF-beta1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-kappaB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].

O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3CC[C@@](C)(O)[C@@]31[H])C2=C

-20°C,2°C to 8°C

12352200