Midostaurin (Standard)

MedChem Express

Midostaurin (Standard) [120685-11-2]

5

Research Use Only

Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCalpha/beta/gamma , Syk , Flk-1 , Akt , PKA , c-Kit , c-Fgr , c-Src , FLT3 , PDFRbeta and VEGFR1/2 with IC 50 s ranging from 22-500 nM [1] [2] . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects [3] .

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