Milciclib (maleate) [1253645-38-3]
HY-10424A
CAS Number1253645-38-3
Product group Chemicals
Molecular Weight576.65
Overview
- SupplierMedChem Express
- Product NameMilciclib (maleate) [1253645-38-3]
- Delivery Days Customer9
- CAS Number1253645-38-3
- CertificationResearch Use Only
- Molecular FormulaC29H36N8O5
- Molecular Weight576.65
- Scientific DescriptionMilciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.
- SMILESO=C(NC)C1=NN(C2=C1C(C)(CC3=CN=C(N=C23)NC4=CC=C(C=C4)N5CCN(CC5)C)C)C.OC(/C=C\C(O)=O)=O
- UNSPSC12352200