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Chemical Structure
Chemical Structure
Chemical Structure

Mildronate dihydrate [86426-17-7]

Research Use Only
CDX-M0558
Chemodex
CAS Number86426-17-7
Product group Chemicals
Estimated Purity>98%
Molecular Weight182.22
Price on request
Packing Size
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Overview

  • Supplier
    Chemodex
  • Product Name
    Mildronate dihydrate [86426-17-7]
  • Delivery Days Customer
    10
  • CAS Number
    86426-17-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C6H14N2O2 . 2H2O
  • Molecular Weight
    182.22
  • Scientific Description
    Chemical. CAS: 86426-17-7. Formula: C6H14N2O2 . 2H2O. MW: 182.22. Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimers disease. - Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimers disease.
  • SMILES
    [O-]C(CCN[N+](C)(C)C)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200