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MITF antibody [C5 + D5]

GTX01743
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
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Product group Antibodies
TargetMITF
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Overview

  • Supplier
    GeneTex
  • Product Name
    MITF antibody [C5 + D5]
  • Delivery Days Customer
    9
  • Application Supplier Note
    IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Clone ID
    C5 + D5
  • Conjugate
    Unconjugated
  • Gene ID4286
  • Target name
    MITF
  • Target description
    melanocyte inducing transcription factor
  • Target synonyms
    bHLHe32; class E basic helix-loop-helix protein 32; CMM8; COMMAD; melanogenesis associated transcription factor; MI; microphtalmia-associated transcription factor; microphthalmia-associated transcription factor; MITF-A; WS2; WS2A
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDO75030
  • Protein Name
    Microphthalmia-associated transcription factor
  • Scientific Description
    The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes. Tanaka M et al., 2019 Nov, Pathol Int
    Read more
  • Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies. Speiser J et al., 2019 Aug, J Cutan Pathol
    Read more
  • Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas. Helbig D et al., 2018 Dec, J Cutan Pathol
    Read more
  • New observations in tumor cell plasticity: mutational profiling in a case of metastatic melanoma with biphasic sarcomatoid transdifferentiation. Rupp NJ et al., 2018 Oct, Virchows Arch
    Read more
  • VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family. Esumi N et al., 2007 Jan 19, J Biol Chem
    Read more
  • Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. Wellbrock C et al., 2005 Aug 29, J Cell Biol
    Read more

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