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MITF antibody [C5 + D5]

Name: MITF antibody [C5 + D5]
SKU: GTX01743_G10
Availability: BackOrder

GTX01743

ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetMITF

Overview

Supplier
GeneTex
Product Name
MITF antibody [C5 + D5]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Clone ID
C5 + D5
Conjugate
Unconjugated
Gene ID4286
Target name
MITF
Target description
melanocyte inducing transcription factor
Target synonyms
CMM8, COMMAD, MI, MITF-A, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, melanogenesis associated transcription factor, microphtalmia-associated transcription factor
Host
Mouse
Isotype
IgG1
Protein IDO75030
Protein Name
Microphthalmia-associated transcription factor
Scientific Description
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Tanaka M, Matsumura M, Okudela K, et al. Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes. Pathol Int. 2019,69(11):667-671. doi: 10.1111/pin.12850
Read this paper
Speiser J, Tao J, Champlain A, et al. Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies. J Cutan Pathol. 2019,46(8):555-562. doi: 10.1111/cup.13462
Read this paper
Helbig D, Mauch C, Buettner R, et al. Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas. J Cutan Pathol. 2018,45(12):880-885. doi: 10.1111/cup.13346
Read this paper
Rupp NJ, Rechsteiner M, Freiberger SN, et al. New observations in tumor cell plasticity: mutational profiling in a case of metastatic melanoma with biphasic sarcomatoid transdifferentiation. Virchows Arch. 2018,473(4):517-521. doi: 10.1007/s00428-018-2376-3
Read this paper
Esumi N, Kachi S, Campochiaro PA, et al. VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family. J Biol Chem. 2007,282(3):1838-50.
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Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol. 2005,170(5):703-8.
Read this paper

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MITF antibody [C5 + D5]

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