MITF antibody [C5 + D5]
GTX01743
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetMITF
Overview
- SupplierGeneTex
- Product NameMITF antibody [C5 + D5]
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Clone IDC5 + D5
- ConjugateUnconjugated
- Gene ID4286
- Target nameMITF
- Target descriptionmelanocyte inducing transcription factor
- Target synonymsCMM8, COMMAD, MI, MITF-A, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, melanogenesis associated transcription factor, microphtalmia-associated transcription factor
- HostMouse
- IsotypeIgG1
- Protein IDO75030
- Protein NameMicrophthalmia-associated transcription factor
- Scientific DescriptionThe protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes. Tanaka M et al., 2019 Nov, Pathol IntRead more
- Is melanocyte density our last hope? Comparison of histologic features of photodamaged skin and melanoma in situ after staged surgical excision with concurrent scouting biopsies. Speiser J et al., 2019 Aug, J Cutan PatholRead more
- Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas. Helbig D et al., 2018 Dec, J Cutan PatholRead more
- New observations in tumor cell plasticity: mutational profiling in a case of metastatic melanoma with biphasic sarcomatoid transdifferentiation. Rupp NJ et al., 2018 Oct, Virchows ArchRead more
- VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family. Esumi N et al., 2007 Jan 19, J Biol ChemRead more
- Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. Wellbrock C et al., 2005 Aug 29, J Cell BiolRead more

![WB analysis of A375 cell lysate using GTX13703 MITF antibody [21D1418]. Dilution : 4 microg/ml](https://www.genetex.com/upload/website/prouct_img/normal/GTX13703/GTX13703_990_WB_w_23060620_374.webp)



![IHC-P analysis of human malignant melanoma tissue using GTX01904 MITF antibody [34CA5]. Note nuclear staining of melanoma cells.](https://www.genetex.com/upload/website/prouct_img/normal/GTX01904/GTX01904_20200811_IHC-P_57_w_23053121_316.webp)
![IHC-P analysis of human melanoma tissue using GTX34842 MITF antibody [D5].](https://www.genetex.com/upload/website/prouct_img/normal/GTX34842/GTX34842_20200115_IHC-P_764_w_23060801_548.webp)
![IHC-P analysis of human melanoma tissue using GTX34843 MITF antibody [SPM290].](https://www.genetex.com/upload/website/prouct_img/normal/GTX34843/GTX34843_20200115_IHC-P_766_w_23060801_925.webp)
![IHC-P analysis of human melanoma tissue using GTX34844 MITF antibody [MITF/915].](https://www.genetex.com/upload/website/prouct_img/normal/GTX34844/GTX34844_20200115_IHC-P_765_w_23060801_962.webp)