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Chemical Structure
Chemical Structure
Chemical Structure

Mitomycin C [50-07-7]

Research Use Only
CDX-M0161
Chemodex
CAS Number50-07-7
Product group Chemicals
Molecular Weight334.33
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Packing Size
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Overview

  • Supplier
    Chemodex
  • Product Name
    Mitomycin C [50-07-7]
  • Delivery Days Customer
    10
  • CAS Number
    50-07-7
  • Certification
    Research Use Only
  • Hazard Information
    Warning
  • Molecular Formula
    C15H18N4O5
  • Molecular Weight
    334.33
  • Scientific Description
    Chemical. CAS: 50-07-7. Formula: C15H18N4O5. MW: 334.33. Mitomycin C (MMC) is an antitumor antibiotic. This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5-CpG-3. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication. Mitomycin C causes the cross-linking of double-stranded DNA, which results in mutagenesis, inhibition of DNA synthesis, initiation of DNA repair events, and activation of apoptosis. In tissue culture, this compound decreases cell viability and suppresses mitosis, and causes disorganization of nucleus and the production of giant cells. Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria. Mitomycin C from Streptomyces caespitosus has been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line. - Mitomycin C (MMC) is an antitumor antibiotic. This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5-CpG-3. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication. Mitomycin C causes the cross-linking of double-stranded DNA, which results in mutagenesis, inhibition of DNA synthesis, initiation of DNA repair events, and activation of apoptosis. In tissue culture, this compound decreases cell viability and suppresses mitosis, and causes disorganization of nucleus and the production of giant cells. Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria. Mitomycin C from Streptomyces caespitosus has been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line.
  • SMILES
    NC1=C(C)C(C(N(C[C@@]2([H])[C@]3([H])N2)[C@@]3(OC)[C@@H]4COC(N)=O)=C4C1=O)=O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200