Mitoxantrone

MedChem Express

Mitoxantrone [65271-80-9]

10

65271-80-9

Research Use Only

99.58

C22H28N4O6

444.48

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 microM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity [1] [2] [3] [4] . Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively [5] .

O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O

-20°C

12352200