Mitoxantrone-d8 (hydrochloride)

MedChem Express

Mitoxantrone-d8 (hydrochloride)

5

Research Use Only

C22H21D8ClN4O6

488.99

Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 microM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively[5].

O=C1C2=C(C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O)C(O)=CC=C2O.Cl

12352200