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Mitoxantrone (dihydrochloride)

Research Use Only
HY-13502A
MedChem Express
CAS Number70476-82-3
DownloadMSDS
Product group Chemicals
Estimated Purity99.55
Molecular Weight517.40
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Mitoxantrone (dihydrochloride) [70476-82-3]
  • Delivery Days Customer
    10
  • CAS Number
    70476-82-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.55
  • Molecular Formula
    C22H30Cl2N4O6
  • Molecular Weight
    517.40
  • Scientific Description
    Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 microM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity [1] [2] [3] [4] . Mitoxantrone dihydrochloride also has anti- orthopoxvirus activity with EC 50 s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively [5] .
  • SMILES
    O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200