Mitoxantrone (dihydrochloride) [70476-82-3]
HY-13502A
CAS Number70476-82-3
Product group Chemicals
Estimated Purity98.98
Molecular Weight517.40
Overview
- SupplierMedChem Express
- Product NameMitoxantrone (dihydrochloride) [70476-82-3]
- Delivery Days Customer10
- CAS Number70476-82-3
- CertificationResearch Use Only
- Estimated Purity98.98
- Molecular FormulaC22H30Cl2N4O6
- Molecular Weight517.40
- Scientific DescriptionMitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 microM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively[5].
- SMILESO=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200
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