Mitoxantrone (dihydrochloride) (Standard)

MedChem Express

Mitoxantrone (dihydrochloride) (Standard) [70476-82-3]

9

Research Use Only

Mitoxantrone (dihydrochloride) (Standard) is the analytical standard of Mitoxantrone (dihydrochloride). This product is intended for research and analytical applications. Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 microM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity [1] [2] [3] [4] . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 microM and and 0.8 microM for cowpox and monkeypox, respectively [5] .

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