Bio-Connect

MK-0752 [471905-41-6]

HY-10974
MedChem Express
CAS Number471905-41-6
Product group Chemicals
Estimated Purity99.35
Molecular Weight442.90
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MK-0752 [471905-41-6]
  • Delivery Days Customer
    10
  • CAS Number
    471905-41-6
  • Category Supplier
    CHEMICAL,general_chemicals_reagents
  • Certification
    Research Use Only
  • Estimated Purity
    99.35
  • Molecular Formula
    C21H21ClF2O4S
  • Molecular Weight
    442.90
  • Scientific Description
    MK-0752 is a potent, orally active and specific gamma-secretase inhibitor, showing dose-dependent reduction of Abeta40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Abeta in vivo[1][2].
  • SMILES
    O=S([C@@]1(C2=C(C=CC(F)=C2)F)CC[C@@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O
  • Storage Instruction
    -20°C, 3 years; 4°C, 2 years (Powder)
  • UNSPSC
    12352200