MK-8033 hydrochloride

Biorbyt

MK-8033 hydrochloride

16

1283000-43-0

Research Use Only

C25H22ClN5O3S

507.9918828

MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM.

O=S(=O)(NCC1C=CC=CN=1)CC1C=C2C(=O)C3C(C=CC2=CC=1)=NC=C(C1C=NN(C)C=1)C=3.Cl

12352200