MK-8141 [903579-36-2]
HY-12172
CAS Number903579-36-2
Product group Chemicals
Molecular Weight620.61
Overview
- SupplierMedChem Express
- Product NameMK-8141 [903579-36-2]
- Delivery Days Customer5
- CAS Number903579-36-2
- CertificationResearch Use Only
- Molecular FormulaC35H39Cl2N3O3
- Molecular Weight620.61
- Scientific DescriptionMK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
- SMILESO=C(C1=C(C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)C[C@]4([H])CNC[C@@]1([H])N4)N(C5CC5)CC6=CC=CC(C)=C6C
- UNSPSC12352200