MK-8825 [1380887-60-4]

MedChem Express

MK-8825 [1380887-60-4]

9

1380887-60-4

Research Use Only

C31H30F2N6O3

572.61

MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin (HY-10448)-evoked dermal blood flow with an EC50 value of about 7.4 microM. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine[1][2].

O=C1[C@]2(CC3=CC(NC(CN4[C@@](CNC5(CCCC5)C4=O)(C6=CC(F)=CC(F)=C6)C)=O)=CN=C3C2)C7=CC=CN=C7N1

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