MK-886

MedChem Express

MK-886 [118414-82-7]

10

118414-82-7

Research Use Only

99.77

C27H34ClNO2S

472.08

MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP ( IC 50 of 30 nM) and leukotriene biosynthesis ( IC 50 s of 3 nM and 1.1 microM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARalpha antagonist and can induce apoptosis [1] [2] [3] .

CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1

-20°C,2°C to 8°C

12352200