MK 886

AbMole BioScience

MK 886

9

118414-82-7

Chemical

Research Use Only

>98%

C27H34ClNO2S

472.08

Mk-886 (L 663536) is a potent, cellular permeable, orally active inhibitor of FLAP (IC50 at 30 nM) and leukotriene biosynthesis (IC50 at 3 nM and 1.1uM in whole white blood cells and human whole blood, respectively). Mk-886 is also a non-competitive PPARalfa antagonist that can induce apoptosis.

CC(C)C1=CC=C2[N](CC3=CC=C(Cl)C=C3)C(=C(SC(C)(C)C)C2=C1)CC(C)(C)C(O)=O

12352200