MK2-IN-3 (hydrate)

MedChem Express

MK2-IN-3 (hydrate) [1186648-22-5]

10

1186648-22-5

Research Use Only

99.0

C21H18N4O2

358.39

MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 microM), MK-5 (IC50=0.081 microM), ERK2 (IC50=3.44 microM), MNK1(IC50=5.7 microM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].

O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.O

-20°C

12352200