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MKC8866

HY-104040
MedChem Express
CAS Number1338934-59-0
DownloadMSDS
Product group Chemicals
Estimated Purity99.95
Molecular Weight361.35
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MKC8866 [1338934-59-0]
  • Delivery Days Customer
    10
  • CAS Number
    1338934-59-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.95
  • Molecular Formula
    C18H19NO7
  • Molecular Weight
    361.35
  • Scientific Description
    MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC 50 of 0.29?microM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC 50 of 0.52?microM and unstresses RPMI 8226 cells with an IC 50 of 0.14?microM [1] . MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth [2] .
  • SMILES
    O=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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MKC8866 [1338934-59-0]
Product group Chemicals
TargetMol Chemicals
MKC8866 [1338934-59-0]T15594
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Estimated Purity99.28%
Molecular Weight361.35
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