MKC8866
HY-104040
CAS Number1338934-59-0
Product group Chemicals
Estimated Purity99.95
Molecular Weight361.35
Overview
- SupplierMedChem Express
- Product NameMKC8866 [1338934-59-0]
- Delivery Days Customer10
- CAS Number1338934-59-0
- CertificationResearch Use Only
- Estimated Purity99.95
- Molecular FormulaC18H19NO7
- Molecular Weight361.35
- Scientific DescriptionMKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC 50 of 0.29?microM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC 50 of 0.52?microM and unstresses RPMI 8226 cells with an IC 50 of 0.14?microM [1] . MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth [2] .
- SMILESO=CC1=C(O2)C(C(C)=C(CC(N3CCOCC3)=O)C2=O)=CC(OC)=C1O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200