ML-345 [1632125-79-1]

TargetMol Chemicals

ML-345 [1632125-79-1]

14

1632125-79-1

Chemical

Research Use Only

ML-345

C21H22FN3O5S2

479.55

Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-beta, a peptide implicated in Alzheimers disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.[2]

3 years

Fc1ccc2sn(-c3cc(ccc3N3CCOCC3)S(=O)(=O)N3CCOCC3)c(=O)c2c1

-20°C

12352200