ML-SI3

MedChem Express

ML-SI3 [891016-02-7]

10

891016-02-7

Research Use Only

99.93

C23H31N3O3S

429.58

ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 microM and 1.7 microM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 microM and 9.4 microM, respectively[1][2].

O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O

-20°C,2°C to 8°C

12352200