ML281

MedChem Express

ML281 [1404437-62-2]

10

1404437-62-2

Research Use Only

99.91

C22H19N3O2S

389.47

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 microM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]

O=C1NC2=CC=CC=C2N=C1C3=CC(C(C)C)=CC=C3NC(C4=CC=CS4)=O

-20°C,2°C to 8°C

12352200