ML289

MedChem Express

ML289 [1382481-79-9]

10

1382481-79-9

Research Use Only

98.38

C22H23NO3

349.42

ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 ( IC 50 =0.66 microM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5 [1] . ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C(N1C[C@H](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2

-20°C,2°C to 8°C

12352200