ML314 [1448895-09-7]

MedChem Express

ML314 [1448895-09-7]

10

1448895-09-7

Research Use Only

99.52

C24H28N4O3

420.50

ML314 is a potent, BBB-penetrant and beta-arrestin biased molecule agonist of NTR1 (EC50 = 1.9 microM). ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions[1][2].

COC1=CC=CC=C1N2CCN(C3=C4C=C(OC)C(OC)=CC4=NC(C5CC5)=N3)CC2

-20°C,2°C to 8°C

12352200