ML324 --- JMJD2 Histone Demethylase Inhibitor

Bioss

ML324 --- JMJD2 Histone Demethylase Inhibitor [1222800-79-4]

16

Research Use Only

98.0

ML324 is a potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0.92 microM toward JMJD2E. It has excellent in vitro ADME properties, and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.

-20°C

51202000