ML339

MedChem Express

ML339 [2579689-83-9]

10

2579689-83-9

Research Use Only

99.88

C26H32ClN3O5

502.00

ML339 is a selective CXCR6 antagonist with an IC 50 of 140 nM. ML339 antagonizes beta-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC 50 of 0.3 microM and 1.4 microM, respectively. ML339 shows weaker activity against the recruitment of beta-arrestin in mouse CXCR6 receptors, with an IC 50 of 18 microM. ML339 has no inhibitory effect on CXCR5 , CXCR4 , CXCR6 and apelin receptor (APJ) , with IC 50 >79 microM. ML339 has the potential to promote the development of prostate cancer research [1] [2] .

O=C(C1=CC(OC)=C(C(OC)=C1)OC)N[C@@H]2C[C@@H](CCC[C@H]3C2)N3CC(NC4=CC=CC=C4Cl)=O

-20°C,2°C to 8°C

12352200