ML346

MedChem Express

ML346 [100872-83-1]

10

100872-83-1

Research Use Only

98.25

C14H12N2O4

272.26

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 microM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1].

O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O

-20°C,2°C to 8°C

12352200