ML351

MedChem Express

ML351 [847163-28-4]

10

847163-28-4

Research Use Only

99.16

C15H11N3O

249.27

ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2[1]. ML351 prevents dysglycemia and reduces beta-cell oxidative stress in nonobese diabetic mouse model of T1D[2].

N#CC1=C(NC)OC(C2=C3C=CC=CC3=CC=C2)=N1

-20°C,2°C to 8°C

12352200