ML364

MedChem Express

ML364 [1991986-30-1]

10

1991986-30-1

99.96

C24H18F3N3O3S2

517.54

ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor ( IC 50 =1.1 microM) with anti-proliferative activity, which direct binds to USP2 ( K d =5.2 microM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP [1] [2] .

O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O

-20°C,2°C to 8°C

12352200