ML380

MedChem Express

ML380 [1627138-52-6]

10

1627138-52-6

Research Use Only

99.91

C23H25F3N4O3S

494.53

ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR , with EC 50 s of 190 and 610 nM for human and rat M5 , respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR [1] [2] [3] .

O=C(C1CCN(S(=O)(C2=CC3=C(NN=C3)C=C2)=O)CC1)N(CC)CC4=CC=CC=C4C(F)(F)F

-20°C,2°C to 8°C

12352200