ML786 (dihydrochloride) [1237536-18-3]

MedChem Express

ML786 (dihydrochloride) [1237536-18-3]

10

1237536-18-3

Research Use Only

C29H31Cl2F3N4O3

611.48

ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EdeltaB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=[1].

O=C(CC1)NC2=C1C(OC3=CC=C(CC[C@@H](NC(C4=CC(C(F)(F)F)=CC(C(C)(C)N)=C4)=O)C5)C5=C3)=CC=N2.Cl.Cl

12131703