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MLS6357

HY-175504
MedChem Express
Molecular Weight395.90
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MLS6357
  • Delivery Days Customer
    999
  • Certification
    Research Use Only
  • Molecular Formula
    C18H22ClN3O3S
  • Molecular Weight
    395.90
  • Scientific Description
    MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based beta-arrestin recruitment assay with IC50s of 13 and 14 microM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 microM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 microM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].
  • SMILES
    O=C(C1=C(NC(C)=C1S(NC2=CC(Cl)=C(C=C2)C)(=O)=O)C)N3CCCC3
  • UNSPSC
    12352200

MSDS

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