MMP3 antibody

GeneTex

MMP3 antibody

9

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3.

WB: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MMP3

matrix metallopeptidase 3

CHDS6; matrix metalloproteinase 3 (stromelysin 1, progelatinase); MMP-3; proteoglycanase; SL-1; STMY; STMY1; STR1; stromelysin-1; transin-1

Rabbit

IgG

Stromelysin-1

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.

Human

-20°C or -80°C,2°C to 8°C

12352203