MMRi62

AbMole BioScience

MMRi62

9

352693-80-2

Chemical

Research Use Only

C21H15Cl2N3O

396.27

MMRi62 is a ferroptosis inducer targeting MDM2-MDM4 (negative regulator of the oncogene p53), which induces ferroptosis accompanied by an increase in reactive oxygen species (ROS) and lysosomal degradation of ferritin heavy chain (FTH1).MMRi62 displays p53-independent apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells. MMRi62 shows p53-independent pro-apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells.) In addition, MMRi62 caused proteasomal degradation of mutant p53 and was active in vivo in an in situ xenograft PDAC mouse model characterized by high-frequency mutations in KRAS and TP53.

OC1=C(C=CC2=C1N=CC=C2)C(NC3=CC=CC=N3)C4=C(Cl)C(=CC=C4)Cl

4°C, protect from light

12352200