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MMRi64 [430458-66-5]

MMRi64 [430458-66-5]

T28078
TargetMol Chemicals
Estimated Purity99.61%
DownloadMSDS
Product group Chemicals
Molecular Weight410.3
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    MMRi64 [430458-66-5]
  • Delivery Days Customer
    4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    MMRi64
  • Estimated Purity
    99.61%
  • Molecular Formula
    C22H17Cl2N3O
  • Molecular Weight
    410.3
  • Scientific Description
    MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.
  • Shelf life instruction
    3 years
  • SMILES
    C(NC1=CC(C)=CC=N1)(C2=C(O)C3=C(C=C2)C=CC=N3)C4=C(Cl)C(Cl)=CC=C4
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Wu W et al., 2015 Dec 31, Cell Death Dis
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